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Scheda Riassuntiva
Anno Accademico 2019/2020
Scuola Scuola di Ingegneria Industriale e dell'Informazione
Insegnamento 099279 - TECHNOLOGIES FOR REGENERATIVE MEDICINE
Docente Raimondi Manuela Teresa
Cfu 10.00 Tipo insegnamento Monodisciplinare

Corso di Studi Codice Piano di Studio preventivamente approvato Da (compreso) A (escluso) Insegnamento
Ing Ind - Inf (Mag.)(ord. 270) - MI (471) BIOMEDICAL ENGINEERING - INGEGNERIA BIOMEDICA*AL099279 - TECHNOLOGIES FOR REGENERATIVE MEDICINE

Obiettivi dell'insegnamento

The goal of this course it to introduce the student to the design of technologies in the field of regenerative medicine, such as automated cell culture systems and innovative substrates for cell culture. The course aims at addressing the formative aspects related to the clinical application of such technologies. Also, the course focuses on fundamental aspects of modelling the cell microenvironment and on the design of advanced systems for the development of bioartificial organs.


Risultati di apprendimento attesi

DdD1: After passing the exam, the student possesses the knowledge and comprehension of:

1) the clinical risks associated to a specific regenerative therapy;

2) the cell sources that can be potentially used on humans in a specific regenerative therapy;

3) mass transport in a cellular product and the relevant boundary conditions;

5) the clinical results of all the phases of development of a specific regenerative therapy.

Dd2: After passing the exam, the student will be able to apply the knowledge acquired, with reference to any tissue/organ of the human body:

1) to locate the clinical risks associated to a specific regenerative therapy;

2) to locate the cell sources that can be potentially used on humans in a specific regenerative therapy;

3) to write the equation describing mass transport in a cellular product and relevant boundary conditions;

4) to calculate and graph the concentration profile of a solute of interest within a cellular product used in a specific regenerative therapy;

5) to describe and discuss the clinical results of all the phases of development of a specific regenerative therapy.


Argomenti trattati

Introduction to regenerative medicine.

Rational for the use of biological material to replace tissue and organ function. The transplant crisis. Pioneering examples of regenerative therapies. Process schematization in regenerative therapies. Ethics and regulation for the development of new commercial products for a regenerative therapy. 

The fundamental constituents of a regenerative therapy: biomaterials, cells and signals.

Biomaterials for regenerative medicine. Cell manipulation, cell source, stem cells and differentiated cells, techniques for cell isolation and separation, cell expansion. Mass transport and conditioning of cellularized constructs. Strategies to model and engineer the cell microenvironment.

Tissue dynamics.

Morphogenesis. Homeostasis. Repair. Bioengineering techniques to model and to engineer dynamic states of tissues. Body systems: basic morphogenesis, macro anatomy, micro anatomy and cell populations, physiology, pathology, and conventional therapy.

Clinical application.

With reference to specific organs and tissues of the main systems: basic morphogenesis, macro anatomy, micro anatomy, physiology, pathology, conventional therapy, new strategies of regenerative medicine.

Integumentary system. Bioengineering strategies to repair or regenerate the skin, cornea and mammary gland.

Nervous system. Bioengineering strategies to repair or regenerate the peripheral nerves and the spinal cord.

Muskulo-skeletal system. Bioengineering strategies to repair or regenerate bone, cartilage, and skeletal muscle.

Circulatory system. Bioengineering strategies to repair or regenerate the heart muscle, valves, and blood vessels.

Endocrine system. Bioengineering strategies to repair or regenerate the endocrine function of the pancreas.

Gastrointestinal system. Bioengineering strategies to repair or regenerate the esophagus, stomach, intestine and liver.

Urogenital system. Bioengineering strategies to repair or regenerate the kidney and bladder.

Respiratory system. Bioengineering strategies to repair or regenerate the trachea and lungs.


Prerequisiti

Biology and Physiology. Transport phenomena in biological systems.


Modalità di valutazione

The final exam will be in the form of a written list of open questions that have to be answered in English. The student will be asked to:

1) locate the clinical risks associated to a specific regenerative therapy;

2) locate the cell sources that can be potentially used on humans in a specific regenerative therapy;

3) write the equation describing mass transport in a cellular product and relevant boundary conditions;

4) calculate and graph the concentration profile of a solute of interest within a cellular product used in a specific regenerative therapy;

5) describe and discuss the clinical results of all the phases of development of a specific regenerative therapy.


Bibliografia

Forme didattiche
Tipo Forma Didattica Ore di attività svolte in aula
(hh:mm)
Ore di studio autonome
(hh:mm)
Lezione
55:00
82:30
Esercitazione
45:00
67:30
Laboratorio Informatico
0:00
0:00
Laboratorio Sperimentale
0:00
0:00
Laboratorio Di Progetto
0:00
0:00
Totale 100:00 150:00

Informazioni in lingua inglese a supporto dell'internazionalizzazione
Insegnamento erogato in lingua Inglese
Disponibilità di materiale didattico/slides in lingua inglese
Disponibilità di libri di testo/bibliografia in lingua inglese
Possibilità di sostenere l'esame in lingua inglese
schedaincarico v. 1.6.5 / 1.6.5
Area Servizi ICT
03/12/2020