Section 1. Introductory concepts and motivations.
1.1. General requirements of a simulation environment for procedure optimization, device testing and/or training.
1.2. Traditional in-vivo animal testing and related limitations.
1.2. The current regulatory scenario.
Section 2. Experimental laboratory platforms. (subject of the experimental module)
Section 3. In-silico virtual phantoms.
3.1. Introduction to numerical modelling approaches.
3.2. Brief review of large strain theory and constitutive modeling for cardiovascular tissues.
3.3. Finite element modeling: theory, implementation and introductory hands-on sessions.
3.4. Geometrical reconstruction of cardiovascular structures from medical imaging.
3.5. Realistic modeling of boundary conditions.
3.6. Criteria for the implementation of numerical models of surgical devices and procedures: matching high-fidelity with practical goals.
Section 4. Integration of experimental and computational methods.
4.1. Criteria for setting up integrated studies exploiting the complementarities of the two approaches.
4.2. Techniques for data integration: critical matching of quantitative information from different approaches.
4.3. The use of experiments for validation of the models: analysis of real-world case studies.
4.4. The use of models for interpreting experimental data: analysis of real-world case studies.
Tutorials and other activities
Class tutorials deal about the application to cases belonging to the real clinical world, including the simulation of recent catheter-based, minimally invasive and reparative cardiovascular procedures.
Laboratory visits are provided for, with practical demonstrations of real experimental and computational procedures.
Seminars will be given by professionals from the industrial and clinical arena.