logo-polimi
Loading...
Risorse bibliografiche
Risorsa bibliografica obbligatoria
Risorsa bibliografica facoltativa
Scheda Riassuntiva
Anno Accademico 2017/2018
Scuola Scuola di Ingegneria Industriale e dell'Informazione
Insegnamento 096055 - BIOENGINEERING OF PHYSIOLOGICAL CONTROL SYSTEMS
Docente Baselli Giuseppe
Cfu 5.00 Tipo insegnamento Monodisciplinare

Corso di Studi Codice Piano di Studio preventivamente approvato Da (compreso) A (escluso) Insegnamento
Ing Ind - Inf (Mag.)(ord. 270) - MI (471) BIOMEDICAL ENGINEERING - INGEGNERIA BIOMEDICA*AZZZZ096055 - BIOENGINEERING OF PHYSIOLOGICAL CONTROL SYSTEMS
Ing Ind - Inf (Mag.)(ord. 270) - MI (476) ELECTRONICS ENGINEERING - INGEGNERIA ELETTRONICA*AZZZZ096055 - BIOENGINEERING OF PHYSIOLOGICAL CONTROL SYSTEMS

Programma dettagliato e risultati di apprendimento attesi

096055 – BIOENGINEERING OF PHYSIOLOGICAL CONTROL SYSTEMS – 5 CFU – BASELLI GIUSEPPE

 

 

Approccio bioingegneristico ai sistemi fisiologici di controllo: vengono richiamati temi generali di teoria dei sistemi di controllo e applicati a sistemi fisiologici. Temi generali - Analisi e simulazione dei sistemi dinamici e dei sistemi di controllo. Identificazione di sistemi in anello aperto e chiuso. Cenni a monitoraggio e regolazione di parametri vitali. Sistemi fisiologici - Struttura generale del sistema nervoso autonomo, simpatico e parasimpatico. Funzione e controllo cardiovascolare, regolazione barocettiva, circolazione periferica, regolazione dei volumi ematici, meccanismi chemocettivi, regolazione metabolica.

 

 

Bioengineering approach to physiological control systems: general topics of control system theory are recalled and applied to physiological systems. General topics - Analysis and simulation of dynamic systems and control systems. Open and closed loop system identification. Elements of monitoring and regulation of vital parameters. Physiological systems - General structure of the autonomic nervous systems, sympathetic and parasympathetic. Cardiovascular function and control, baroreceptive regulation, peripheral circulation, regulation of blood volumes, chemoceptive mechanism, metabolic regulation.

 

 

Detailed Program

 

(ref. to pp. of M.C. Khoo’s textbook; or other source)

 

 

 

Introduction: course aims, prerequisites, methods and physiological applications

 

Introduction to closed loop (CL) control systems (1-11)

 

The Autonomic nervous system (ANS): overview of physiology and anatomy (slides)

 

Mathematical Models: physical models and analogs, black-box or data models

 

Basic linear elements: analogs of resistance, capacitance, and inductance (13-19)

 

Concept of system state. Ordinary Differential Equations (ODE)

 

State space (SS) models. The core role of integration (28-30)

 

Linear time invariant (LTI) models: impulse response and transfer function (23-28)

 

PC-Lab - Numerical Simulation of Models through Matlab Simulink

 

Lumped elements in CV models - Windkessel models of arterial and peripheral response to the beating heart (Westerhof's review par.1, 2, 3, 6, 7, 8; outline par. 4, 5)

 

Peripheral circulation, time constants - Mean systemic pressure and CO-VR WP in more detail (Mark's text p 3-5 + 12-22)

 

Heart contractility and P-V loops; heart-lung pumping unit (Mark's text p 29-36 + 38-42). - Global description of the intact CV system (Mark's 49-53 + 55-63)

 

Seminar on modeling and monitoring of CV regulation mechanisms

 

Equilibrium - Static analysis and working point (WP) of closed loop systems (39-42)

 

WP Example 1 - Cardiac output and venous return WP by Guyton's model (49-55)

 

WP Example 2 - Plasmatic glucose and insulin WP (55-58)

 

Time domain analysis and transients in open and closed loop (lucidi, 69-80)

 

Disturbance compensation and damping vs. closed loop gain (lucidi, 86-87)

 

Baroreflex, physiological and anatomical outline. Evaluation of the baroreflex sensitivity (BRS): response to phenilephrine, ectopic beat turbulence, Valsalva (slides)

 

Frequency domain analyses, Bode plots (slides e 108-111)

 

Vagal and sympathetic frequency response of the sinus node (Berger et al., Saul et al.)

 

Sinus respiratory arrhythmia physiology overview (slides).

 

Saul's model of sinus respiratory arrhythmia and baroreflex (slides e 119-123)

 

Overview of stability and linearization - Stability analysis of CL LTI systems (131-133)

 

Root locus (134-137) - Nyquist criterion (139-143 e slides)

 

Gain and phase margins - Effect of delays in a CL

 

Example 1: Stability of pupil dilation control (146-150)

 

Example 2; Stability of the chemoreflex and Cheyne-Stokes periodic respiration (151-156)

 

Stability: Example 3: Brief recall about HR and AP variabilities: HF respiration-related waves and LF Mayer waves - Kitney's baroreflex regulation model of LF waves (slides)

 

Overview of model identification general concepts (171-174)

 

Introduction of the closed loop identification problem - Examples of experimental setups opening the loop (182-187)

 

PC Lab - Matlab Control System Toolbox

 

Identification of dynamic systems: prediction error minimization

 

Parametric sensitivity and parameter identification variance (176-178)

 

Need of minimizing the number of parameters

 

Example: the glucose/insulin minimal model (190-193)

 

Linear prediction error models (PEMs) for open-loop system identification (slides)

 

Identifying closed-loop systems by PEMs: the direct approach virtually opening the loop (slides) - Example 1: Chemoreflex identification (193-200)

 

Example 2: Identification of RR-SAP-respiration interactions (slides, paper MBEC, 1994)

 

Overview of CV regulation identification models

 

PC Lab - Matlab System Identification Toolbox

 

PC Lab - CV regulation modeling and analysis (seminar slides)

 


Note Sulla Modalità di valutazione

Written Test - 15 open questions - 2 points each - laude upon quality

                     The written test of the 1st call will be anticipated in two parts: mid-semester, end of semester

                     The written test is valid 1 year. It can be improved in a subsequent call, but a new delivered test will subsititute the former one.

                      Questions in English; answers either in English or in Italian

Oral Discussion - After passing the written test; in the same call or in a further one. Either in English or in Italian.


Bibliografia
Risorsa bibliografica obbligatoriaMichael C. K. Khoo, Physiological Control Systems: Analysis, Simulation, and Estimation, Editore: Wiley, Anno edizione: 1999, ISBN: 978-0-7803-3408-3

Mix Forme Didattiche
Tipo Forma Didattica Ore didattiche
lezione
32.0
esercitazione
12.0
laboratorio informatico
8.0
laboratorio sperimentale
0.0
progetto
0.0
laboratorio di progetto
8.0

Informazioni in lingua inglese a supporto dell'internazionalizzazione
Insegnamento erogato in lingua Inglese
Disponibilità di materiale didattico/slides in lingua inglese
Disponibilità di libri di testo/bibliografia in lingua inglese
Possibilità di sostenere l'esame in lingua inglese
Disponibilità di supporto didattico in lingua inglese
schedaincarico v. 1.6.5 / 1.6.5
Area Servizi ICT
19/01/2021