Risorse bibliografiche
Risorsa bibliografica obbligatoria
Risorsa bibliografica facoltativa
Scheda Riassuntiva
Anno Accademico 2020/2021
Scuola Scuola di Ingegneria Industriale e dell'Informazione
Docente Morbidelli Massimo
Cfu 5.00 Tipo insegnamento Monodisciplinare

Corso di Studi Codice Piano di Studio preventivamente approvato Da (compreso) A (escluso) Insegnamento
Ing Ind - Inf (1 liv.)(ord. 270) - MI (347) INGEGNERIA CHIMICA*AZZZZ055586 - APPLIED PHYSICAL CHEMISTRY

Obiettivi dell'insegnamento

Colloidal dispersions exhibit peculiar physico-chemical properties and can be used for the preparation of materials exhibiting unique properties. The objective of the course is to familiarise the students with this state of matter and make them to understand their physicochemical properties. Interparticle interactions, stability, aggregation and breakage kinteics, and gel formation are analysed with specific reference to the involved fundamental physico-chemical aspects. The discussion is extended to the case of protein dispersions, with specific reference to proteins used in therapeutical applications, like monoclonal antibodies. The treatment is quantitative, and in the tutorials (Esercitazioni) mathematical models are developed and implemented to simulate the formation of colloidal aggregates and gels.

The course has a strong engineering character, which emerges in the second part dedicated to the processes based on aggregation, breakage, gelation and reactive gelation which are used to prepare innovative materials starting from dispersions of polymer nanoparticles. These include porous materials to be used as supports for chromatography and catalysis, thermal insulators, gels or nanoparticles for the controlled delivery of drugs in medicine or for the controlled release of flavors in textiles. On the other hand, in the research project the students will work independently, in small groups closely coached by the assistants. The objective is to learn how to formulate a research project, starting from a given objective, and to develop it, through appropriate experimental activites in silico or in wet laboratories. The presentation of the final results through written reports and oral presentations is also part of the teaching.


Risultati di apprendimento attesi

The lectures will teach the students:

- the foundations of the physico-chemical behavior of colloidal systems

- protein dispersions stability in the development of disorders of the central nervous system and of therapeutic formulations

- make innovative materials and devices through aggregation and gelation of colloidal systems


The research project will allow the students to:

- experience the entire evolution of a research project about the production of a device for a specific application

- learn to conduct a targeted literature search

- learn how to define the data needed to reach the project objective

- collect the required data through wet laboratory or in silico experiements

- learn to present the project results in a written report and an oral presentation in front of the instructors and the class colleagues.

Argomenti trattati


The first part of the course relates to the fundamentals of colloidal science and engineering.

In particular, the following topics are treated:

- Colloidal dispersions and nanotechnology

- DLVO theory

- Interaction potential among colloidal nanoparticles

- Colloidal stability

- Aggregation regimes: DLCA and RLCA

- Kinetic models for aggregation in colloidal systems: population balance equations

- Structure, size and morphology of aggregates

- Role of fluid dynamics in colloid aggregagation: laminar and turbulent flows

- Aggregation and breakage under shear

- Population balance modeling of aggreation and breakage in a colloidal system under shear

- Definition of gel phase and gelation kinetics: the concept of percolation

- Gelation processes

- The reactive gelation process


Next, these concepts are extended to biological systems, i.e. aqueous dispersion of proteins, discussing the following aspects:

- Introduction to protein structure, stability and folding/unfolding mechanisms

- Mechanisms of protein aggregation and aggregate morphology (e.g., globular and fibril)

- Kinetic modeling of protein aggregates formation

- Implications in the processes for the production and formulation of therapeutic proteins, e.g., monoclonal antibodies


Finally, the use of colloidal systems for the preparation of materials with specific application properties is discussed. Examples include:

- Magnetic polymer composites

- Porous supports for catalysis and chromatography

- Thermally insulating materials

- Nanoparticles and gels for controlled delivery of drugy, flavors or fertilizers

- The artificial sky


The lectures are supported by tutorials (Esercitazioni) where population balance simulation mathematical models for colloidal aggregation and breakage processes are formulated and implemented (preferably using Matlab)


Research Project (Laboratorio di Progetto)

The students divided in groups of 3/4 are given a project about the production of a polymeric device throgh the technologies discussed in the lectures. Applications may include: porous materials, carriers for drug delivery, adhesives, magnetic polymer, textiles with controlled flavor release and drug formulation. The students work independently with the close advice of assistants having coaching and colsulting functions. The project extends to the entire semester and develops according to the following steps:

- literature search

- definition of the strategy to reach the project objective

- definition and planning of the project activity

- in silico or in wet laboratory activity

- delivery of the results: written report and oral presentation


Students are required to be familiar with basic principles of chemistry, physical chemistry and chemical engineering

Modalità di valutazione

The final evaluation consists of two contributions: oral exam on the content of the lectures (60%) and evaluation of the research project report and presentation (40%).


Risorsa bibliografica obbligatoriaMorbidelli M., Polymer Reaction and Colloidal Engineering, Anno edizione: 2019

Lecture Notes

Risorsa bibliografica facoltativaBerg J.C., An Introduction to Interfaces and Colloids: the Bridge to Nanoscience, Editore: World Scientific, Anno edizione: 2010
Risorsa bibliografica facoltativaIsraelachvili J.N., Intermolecular and Surface Forces, Editore: Academic Press, Anno edizione: 2011

Software utilizzato
Nessun software richiesto

Forme didattiche
Tipo Forma Didattica Ore di attività svolte in aula
Ore di studio autonome
Laboratorio Informatico
Laboratorio Sperimentale
Laboratorio Di Progetto
Totale 50:00 75:00

Informazioni in lingua inglese a supporto dell'internazionalizzazione
Insegnamento erogato in lingua Inglese
Disponibilità di materiale didattico/slides in lingua inglese
Disponibilità di libri di testo/bibliografia in lingua inglese
Possibilità di sostenere l'esame in lingua inglese
Disponibilità di supporto didattico in lingua inglese
schedaincarico v. 1.6.8 / 1.6.8
Area Servizi ICT