Ing Ind - Inf (Mag.)(ord. 270) - MI (491) MATERIALS ENGINEERING AND NANOTECHNOLOGY - INGEGNERIA DEI MATERIALI E DELLE NANOTECNOLOGIE
093743 - MOLECULAR FUNCTIONAL MATERIALS
This course aims to explain the fundamental basis of intermolecular interactions and describe how these can be applied to develop diverse supramolecular assemblies spanning from small molecules, metal organic frameworks, soft materials, polymers, nanoparticles and bio-systems. The module will provide a research overview of the current state-of-the-art in supramolecular and self-assembled systems and will give students a wide knowledge on the chemistry behind the assembling processes for constructing molecular functional materials.
Specifically the aims of the course are:
to provide a detailed overview of the fundamental concepts in supramolecular chemistry such as non-covalent interaction, crystal engineering, host-guest chemistry, building units organization.
to provide an extensive overview on the synthesis and application of supramolecular systems and nanomaterials.
to provide the students with the core chemical concepts (organic, inorganic, and supramolecular) for the design and develop of molecular functional materials which arise from the designed interaction of “small” molecules and/or more generally building blocks.
Risultati di apprendimento attesi
After having successfully completed this course and the final examination the student will be able to:
Understand and identify the role of non-covalent interactions in the formation of molecular functional materials.
Know the role of supramolecular chemistry in organic chemistry, chemical biology, materials science and nanotechnology.
Know the working principles in the molecular recognition and self-assembly phenomena and how these can be applied to develop functional molecules for a wide-range of applications.
Know how supramolecular chemistry can impact on crystal engineering; self-assembly and self-organization; molecular recognition; liquid crystals; molecular manipulation and molecular machines; stimuli-responsive materials; self-healing materials; photoresponsive materials; nanoparticles for biomedical applications; superhydrophobic surfaces
Apply the above knowledge to a critical description and discussion of the functional molecular assemblies and related properties, limitations and developments
These learning outcomes are expected to provide the student with the basic knowledge tools necessary for performing future activities aimed at the development of molecular functional materials.
This course is a research-led course with many examples coming from the recent scientific literature. Topics to be covered in this course include:
Overview of intermolecular interactions (g. hydrogen and halogen bonds, aromatic-aromatic interactions; ions-aromatic interactions) in the context of the structural and thermodynamic origin of molecular recognition processes.
Fundamental principles of molecular recognition and self-assembly (complementarity, preorganization, co-operativity)
Principles and applications of supramolecular chemistry including: host-guest chemistry, macrocycles (e.g. crown ether), cavitands, clatrhates, DNA and peptides.
Self-assembly of complex structures and large architectures starting from small building units: cages or interlocked molecules (g. rotaxanes, helicates, molecular polygons, catenanes).
Metal Organic Framework (MOF) - synthesis, properties and applications of modular porous solids (g. storage and separation)
Crystal engineering driven by halogen bond (XB): co-crystals of API, gels, separation and recognition processes driven by XB
Molecular Machines and Molecular Devices: fundamental principles and applications of dynamic systems (molecular elevator, molecular shuttle, molecular logic gates, molecular tweezer).
Synthesis, characterization and applications of nanoparticles (e.g.inorganic and organic nanoparticles, exosomes) in the biomedical field, i.e. drug delivery, diagnostics, biosensing.
Behavior of nanomaterials in the biological environment (interactions with the biomolecules, introduction to the concept of protein corona)
A background in organic and inorganic chemistry, material chemistry and material characterization is preferable.
Material or lecture notes will be made available by the lecturer.
Modalità di valutazione
The examination is an oral discussion about the course topics. The oral exam will be focused on the concepts and technologies related to molecular materials possessing useful functional properties. Particular attentions will be given to the correlation between the (nano)structure, self-organization, and self-assembly of the molecular components and the functional properties of the material.
The student must be able to clearly describe and critically discuss the topics, with the related hypotheses, the critical points, the chemical and physical meaning in the context of supramolecular chemistry.
Tipo Forma Didattica
Ore di attività svolte in aula
Ore di studio autonome
Laboratorio Di Progetto
Informazioni in lingua inglese a supporto dell'internazionalizzazione
Insegnamento erogato in lingua
Disponibilità di materiale didattico/slides in lingua inglese
Possibilità di sostenere l'esame in lingua inglese
Disponibilità di supporto didattico in lingua inglese