Ing Ind - Inf (Mag.)(ord. 270) - BV (478) NUCLEAR ENGINEERING - INGEGNERIA NUCLEARE

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052504 - ADVANCED NUMERICAL METHODS FOR COUPLED PROBLEMS WITH APPLICATION TO LIVING SYSTEMS

Ing Ind - Inf (Mag.)(ord. 270) - MI (471) BIOMEDICAL ENGINEERING - INGEGNERIA BIOMEDICA

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053464 - ADVANCED NUMERICAL METHODS FOR COUPLED PROBLEMS

Ing Ind - Inf (Mag.)(ord. 270) - MI (487) MATHEMATICAL ENGINEERING - INGEGNERIA MATEMATICA

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052504 - ADVANCED NUMERICAL METHODS FOR COUPLED PROBLEMS WITH APPLICATION TO LIVING SYSTEMS

Obiettivi dell'insegnamento

The course is thought for students attending an MSc in Engineering who want to deepen the numerical treatment of coupled problems arising in different engineering applications. The course is divided into two parts: in the first one (5 CFU), numerical methods to address general coupled problems arising in practical scenarios will be introduced and analyzed; in the second part (3 CFU), the general methods introduced in the first part will be applied to a specific context, namely the numerical modeling of the cardiovascular system, which is characterized by several coupling of different nature. This will allow to introduce the students towards projects inspired by the clinical needs. Thus, this course presents a modular structure, so that an MSc could possibly introduce only one of these two moduli among its courses. The students will be addressed during the course towards new and advanced numerical strategies to handle complex coupled problems that could arise in different engineering contexts. In order to have practical answers of the new numerical strategies introduced in this course, several laboratories with the computer will be considered, where the students will utilize some of the new numerical technique in a Finite Elements library.

The learning process will involve lectures on the theory and computer laboratories about the application of examples of numerical methods.

The course could be performed also in a short version by 5 CFU called "053464 - ADVANCED NUMERICAL METHODS FOR COUPLED PROBLEMS". The present description accounts for both the courses (the extended and the short one).

Risultati di apprendimento attesi

For both the version of the course (extended and short), the lectures and the laboratories will provide students with the knowledge and understanding of * Numerical techniques for homogeneous and heterogeneous problems based on domain decomposition; * Numerical approximation of the coupling between a fluid and a structure;

Limited to the extended version of the course, the lectures and the laboratories will provide students also with the knowledge and understanding of

* Numerical treatment of the coupling between geometrically heterogeneous models;

* The electro-mechanical coupled problem in the heart

* Fluid-structure interaction with immersed structures

Moreover, both for the extended and the short courses, the ability to apply the previous knowledge to some examples on the calculator will be stimulated. In particular the student is required to * be able to run executables introduced during laboratories; * critically discuss the results of the numerical experiments above in prespective of the theory;

The instructor expects a broad comprehension of the subjects which should not be limited to the statement of theoretical results. Instead, the acquired knowledge should enable students to express critical judgment. The students are expected to express their answers in a mathematically rigorous and clear way.

Argomenti trattati

In what follow, the topics of the courses will be presented. Part I is common (extended and short version of the course), whereas part II refers only to the extended course

PART I (5 CFU) (Extended and short course)

I Numerical techniques for heterogeneous problems based on domain decomposition I.1 Domain Decomposition methods and formulation of the problem I.2 Interface equation I.3 Weak formulations and Finite Elements approximations I.4 Extensions to the Hooke and Stokes equations I.5 Heterogeneous Domain Decomposition: examples

II Numerical approximation of the coupling between a fluid and a structure II.1 Introduction to the cardiovascular system and examples of applications II.2 Preprocessing: Image reconstruction and mesh generation II.3 A brief review of the numerical approximation of the elasto-dynamics and Navier-Stokes equations II.4 Position of the coupled problem II.5 Arbitrary Lagrangian-Eulerian formulation II.6 The treatment of the geometric coupling II.7 Numerical algorithm based on partitioned schemes. Added mass effect II.8 Monolithic strategies and preconditioning

PART 2 (3 CFU) (Extended course)

III Numerical treatment of the coupling between geometrically heterogeneous models III.1 Numerical treatment of defective boundary conditions III.2 The 1D model for blood dynamics III.3 OD models and outflow conditions

III.4 Geometric multiscale models: 3D-1D and 3D-0D coupling

IV Application to the heart function IV.1 Brief introduction to cardiac physiology IV.2 The electrical propagation and the Bidomain equations IV.3 Numerical strategies for electro-physiology IV.4 The mechanical contraction and electro-mechanical coupled problem IV.5 Electro-mechanical coupling models IV.6 Numerical strategies for the Electro-mechanical coupling

IV.7 Valve modeling

IV.8 Towards an integrated heart functioning modeling

Prerequisiti

The topics that the students should have previously attended refer to the basic concepts of numerical analysis, in particular to:

* solution of linear and non-linear systems;

* approximation of ordinary differential equations;

* approximation of data and integrals;

The students should also have a consolidated knowledge about

* continuous formulation of fluid-dynamics and solid mechanics;

* numerical discretization of partial differential equations;

* Finite Element methods for diffusion-advection and Stokes/Navier-Stokes equations.

Modalità di valutazione

The exam consists only in an oral discussion and is designed to test the student on the knowledge and understanding of:

For both the extended and the short course: * Numerical techniques for heterogeneous problems based on domain decomposition; * Numerical approximation of the coupling between a fluid and a structure;

For the extended course:

* Numerical treatment of the coupling between geometrically heterogeneous models;

* Heart modeling

The instructor expects a broad comprehension of the subjects which should not be limited to the statement of theoretical results. Instead, the acquired knowledge should enable students to express critical judgment. The students are expected to express their answers in a mathematically rigorous and clear way.

Bibliografia

Alfio Quarteroni and Alberto Valli, Domain Decomposition Methods for Partial Differential Equations, Editore: Oxford University Press, Anno edizione: 1999
Quarteroni A., Veneziani A., Vergara C., Geometric multiscale modeling of the cardiovascular system, between theory and practice/Computer Methods in Applied Mechanics and Engineering, Editore: Elsevier, Anno edizione: 2016, Fascicolo: 302
Quarteroni A., Manzoni A., Vergara C., The Cardiovascular System: Mathematical Modeling, Numerical Algorithms, Clinical Applications/Acta Numerica, Anno edizione: 2017, Fascicolo: 26

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