Ing Ind - Inf (1 liv.)(ord. 270) - MI (347) INGEGNERIA CHIMICA
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098501 - APPLIED PHYSICAL CHEMISTRY
Ing Ind - Inf (Mag.)(ord. 270) - MI (471) BIOMEDICAL ENGINEERING - INGEGNERIA BIOMEDICA
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098502 - APPLIED PHYSICAL CHEMISTRY
Ing Ind - Inf (Mag.)(ord. 270) - MI (472) CHEMICAL ENGINEERING - INGEGNERIA CHIMICA
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098501 - APPLIED PHYSICAL CHEMISTRY
Obiettivi dell'insegnamento
The course will analyze the physics of colloidal dispersions. The first part of the course will be devoted to polymer systems, while the second one to protein solutions
Risultati di apprendimento attesi
Lectures and exercise sessions will allow students to:
- know and discuss about interactions between colloidal particles
- know and discuss about kinetic of aggregations in colloidal systems
- know and discuss about manufacture and the formulation of therapeutic proteins
Argomenti trattati
The course discusses the physics of colloidal dispersions and in particular the following aspects: interactions between colloidal particles: van der Waals, electrostatic and hydrodynamic forces; colloidal stability; kinetic models for aggregation in colloidal systems (population balances); structure, size and morphology of aggregates and their experimental characterization; definition of gel phase and gelation kinetics; role of fluid dynamics in colloid aggregation; aggregation kinetic models in laminar and turbulent flows.
In the last part of the course the stability of protein solutions is considered with reference to the following aspects: protein structure and unfolding processes; aggregation during the manufacture and the formulation of therapeutic proteins; aggregates characterization (from globular to fibrils); effect of the environmental physical chemical conditions on the protein propensity to aggregate; technologies for protein aggregate removal.
Prerequisiti
Students are required to know the basic principles of physical chemistry.
Modalità di valutazione
Exams consist in an oral evaluation to assess the knowledge of the contents of the frontal lessons and the ability to solve exercises
Bibliografia
Software utilizzato
Nessun software richiesto
Forme didattiche
Tipo Forma Didattica
Ore di attività svolte in aula
(hh:mm)
Ore di studio autonome
(hh:mm)
Lezione
65:00
97:30
Esercitazione
35:00
52:30
Laboratorio Informatico
0:00
0:00
Laboratorio Sperimentale
0:00
0:00
Laboratorio Di Progetto
0:00
0:00
Totale
100:00
150:00
Informazioni in lingua inglese a supporto dell'internazionalizzazione
Insegnamento erogato in lingua
Inglese
Disponibilità di materiale didattico/slides in lingua inglese
Disponibilità di libri di testo/bibliografia in lingua inglese
Possibilità di sostenere l'esame in lingua inglese
Disponibilità di supporto didattico in lingua inglese
Inglese